Gene information
Official symbol CTSD
Official full name cathepsin D
Gene type protein-coding gene
Chromosome11p15.5
Alias symbolCLN10
Previous symbolCPSD
Gene familyCathepsins
Resources
Entrez Gene 1509
HGNC HGNC:2529
Ensembl ENSG00000117984
Vega OTTHUMG00000044760
UCSC uc001luc.2
GO terms: 37 records
GO Description Category LogP Number of genes Detail
GO:0000323 lytic vacuole GO Cellular Components -7.25784656 30 More
GO:0004175 endopeptidase activity GO Molecular Functions -25.2809598 44 More
GO:0005764 lysosome GO Cellular Components -7.25784656 30 More
GO:0005775 vacuolar lumen GO Cellular Components -10.7475427 18 More
GO:0008233 peptidase activity GO Molecular Functions -21.0463733 46 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0010950 positive regulation of endopeptidase activity GO Biological Processes -13.2452311 34 More
GO:0010952 positive regulation of peptidase activity GO Biological Processes -14.1524623 37 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0030163 protein catabolic process GO Biological Processes -2.20136577 18 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031983 vesicle lumen GO Cellular Components -60.5757669 68 More
GO:0034774 secretory granule lumen GO Cellular Components -58.3093741 66 More
GO:0035580 specific granule lumen GO Cellular Components -14.6396218 15 More
GO:0042159 lipoprotein catabolic process GO Biological Processes -3.41433421 5 More
GO:0042581 specific granule GO Cellular Components -15.6202777 22 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0043202 lysosomal lumen GO Cellular Components -6.22272327 10 More
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO Biological Processes -11.0338596 16 More
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO Biological Processes -14.7594418 39 More
GO:0045121 membrane raft GO Cellular Components -30.0775030 71 More
GO:0045862 positive regulation of proteolysis GO Biological Processes -17.3242033 33 More
GO:0051345 positive regulation of hydrolase activity GO Biological Processes -19.7369783 79 More
GO:0052547 regulation of peptidase activity GO Biological Processes -35.5643317 55 More
GO:0052548 regulation of endopeptidase activity GO Biological Processes -34.9486589 53 More
GO:0060205 cytoplasmic vesicle lumen GO Cellular Components -59.3932782 67 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0070201 regulation of establishment of protein localization GO Biological Processes -24.4831554 82 More
GO:0070820 tertiary granule GO Cellular Components -12.1965297 19 More
GO:0098857 membrane microdomain GO Cellular Components -30.8181788 72 More
GO:0101002 ficolin-1-rich granule GO Cellular Components -6.76434995 14 More
GO:1904724 tertiary granule lumen GO Cellular Components -12.6232675 13 More
GO:1904813 ficolin-1-rich granule lumen GO Cellular Components -6.12299383 11 More
GO:2000116 regulation of cysteine-type endopeptidase activity GO Biological Processes -14.4496812 41 More
GO:2001056 positive regulation of cysteine-type endopeptidase activity GO Biological Processes -11.1582582 17 More
KEGG pathways: 6 records
KEGG Description Category LogP Number of genes Detail
hsa04071 Sphingolipid signaling pathway KEGG Pathway -4.55426967 9 More
hsa04140 Autophagy - animal KEGG Pathway -3.52554737 16 More
hsa04142 Lysosome KEGG Pathway -1.52242432 5 More
hsa04210 Apoptosis KEGG Pathway -6.60042966 12 More
hsa05152 Tuberculosis KEGG Pathway -14.5221547 22 More
hsa05415 Diabetic cardiomyopathy KEGG Pathway -11.4800633 20 More
Drug-Gene interaction
view
Related drugs: 1 record
Drug name Interaction type Source PMID View
streptozocin NCI 3282952 view
Related studies: 5 records
Molecular factor Omics type Application Objective MI type Reference
cathepsin D proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Naseem RH et al. Basic Res Cardiol. 2005
cathepsin D proteomics medium predictor reduced left ventricular ejection fraction[prognosis (bad)] acute ST elevation myocardial infarction Yamac AH et al. Herz. 2015
cathepsin D proteomics good predictor death[prognosis (bad)] acute non-ST elevation myocardial infarction Kundi H et al. Acta Cardiol Sin. 2017
cathepsin D proteomics medium predictor SYNTAX score[other] acute non-ST elevation myocardial infarction Kundi H et al. Acta Cardiol Sin. 2017
cathepsin D proteomics abnormal glucose homeostasis[prognosis (bad)] myocardial infarction Velders MA et al. Ups J Med Sci. 2019
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